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Basic and Clinical Pharmacology 13 E


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ISBN : 9487434239721
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Das Lyell-Syndrom, auch als Epidermolysis acuta toxica oder Syndrom der verbrühten Haut bezeichnet, ist eine seltene, nach dem schottischen Dermatologen Alan Lyell benannte akute Hautveränderung, die durch blasige Ablösungen der Epidermis der Haut („Syndrom der verbrühten Haut“) gekennzeichnet ist.. Die Sterblichkeitsrate beträgt je nach Ausmaß der Schädigung zwischen 25 und 70 %.

Physiologie Allgemeines. Melatonin ist ein Metabolit des Tryptophanstoffwechsels. Seine Bildung wird im Gehirn in der Zirbeldrüse (Epiphyse) durch Licht gehemmt. Bei Dunkelheit wird diese Hemmung aufgehoben, die Produktion steigt an und mit ihr auch die Sekretion des Melatonins.